Fmoc - L - Homophenylalanine, CAS No. 132684-59-4

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132684-59-4

Catalog No. EBD37519

CAS 132684-59-4

Name Fmoc - L - Homophenylalanine

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Basic Information

Synonyms: Fmoc-hPhe-OH n-alpha-fmoc-l-homophenylalanine n-alpha-(9-fluorenylmethoxycarbonyl)-l-homophenylalanine n-alpha-(9-fluorenylmethyloxycarbonyl)-l-homophenylalanine n-alpha-(9-fluorenylmethoxycarbonyl)-(+)-alpha-4-phenylbutyricacid n-fmoc-(l)-homophenylalanine rarechembkpt0051 (s)-2-(fmoc-amino)-4-phenyl-butyricacid fmoc-l-homophenylalanine Fmoc-L-Beta-homo-Phe Fmoc-HoPhe-OH Fmoc-Hphe (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-phenyl-butyricacid 2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoicacid benzenebutanoicacid,alpha-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-

Molecular Formula: C25H23NO4

Molecular Weight: 401.45

MDL Number: MFCD00077046

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-L-Homophenylalanine is a protected amino acid derivative, specifically an analog of phenylalanine with an extended side chain (homolog). Its chemical structure features an L-configuration, a homophenylalanine backbone, and an N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is a fundamental building block in solid-phase peptide synthesis (SPPS) using the Fmoc strategy. The Fmoc group protects the α-amino group during the coupling of subsequent amino acids and can be selectively removed under mild basic conditions (e.g., piperidine). The homophenylalanine residue is incorporated into synthetic peptides to modulate their biological activity, stability, and pharmacokinetic properties, often in the research and development of peptide-based pharmaceuticals and bioactive probes. As a high-purity, specialty chemical, it is primarily supplied to research laboratories and pharmaceutical companies engaged in peptide chemistry. Proper handling requires standard laboratory safety precautions for fine chemicals.

Physical Properties

Boiling Point: 628.284 °C at 760 mmHg

Flash Point: 333.774 °C

Density: 1.255 g/cm3

Storage: 2-8°C