(2R,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid, CAS No. 132622-78-7

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132622-78-7

Catalog No. EBD2209430

CAS 132622-78-7

Name (2R,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid

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Basic Information

Synonyms: (2R,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid (2r,4s)-1-boc-4-amino-pyrrolidine-2-carboxylicacid 1-n-boc-4(s)-amino-pyrrolidine-2(r)-carboxylicacid (2r-trans)-4-amino-1,2-pyrrolidinedicarboxylicacid1-(1,1-dimethylethyl)ester (2r,4s)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid (2r,4s)-4-amino-1,2-pyrrolidinedicarboxylicacid1-(tert-butyl)ester (4s)-1-boc-4-amino-d-proline (2R,4S)-4-amino-1-tert-butoxycarbonyl-pyrrolidine-2-carboxylicacid

Molecular Formula: C10H18N2O4

Molecular Weight: 230.26

MDL Number: MFCD08704543

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

(2R,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid is a chiral, non-proteinogenic amino acid derivative featuring a pyrrolidine ring. It is a white to off-white crystalline powder with a molecular formula of C10H18N2O4. The compound contains both a carboxylic acid and a Boc-protected amine group, making it a versatile building block. This compound is primarily employed as a key chiral intermediate in the synthesis of various pharmaceutical agents. Its rigid, constrained pyrrolidine structure is valuable for introducing specific conformational properties into target molecules. It finds significant application in the research and development of peptide mimetics and protease inhibitors, where it can serve as a proline analog or a scaffold to modulate biological activity and metabolic stability. As a specialty intermediate, it is not considered a commodity chemical. Handling requires standard laboratory precautions for fine chemicals, including the use of personal protective equipment. Its synthesis and use are typically confined to research-scale and process development activities within the pharmaceutical and biotechnology sectors.

Physical Properties

Boiling Point: 371.073°C at 760 mmHg

Flash Point: 178.219°C

Density: 1.233g/cm3