Nalpha-Fmoc-Ndelta-trityl-L-glutamine, CAS No. 132327-80-1

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132327-80-1

Catalog No. EBD2197663

CAS 132327-80-1

Name Nalpha-Fmoc-Ndelta-trityl-L-glutamine

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Basic Information

Synonyms: Nalpha-Fmoc-Ndelta-trityl-L-glutamine n-alpha-9-fluorenylmethoxycarbonyl-n-gamma-trityl-glutamine n-alpha-(9-fluorenylmethoxycarbonyl)-n-gamma-trityl-l-glutamine n-alpha-9-fluorenylmethoxycarbonyl-n-omega-trityl-l-glutamine nalpha-(9-fluorenylmethoxycarbonyl)-nr-trityl-glutamine na-fmoc-ng-trityl-l-glutamine n-alpha-fmoc-n-delta-trityl-l-glutamine n-alpha-fmoc-n-gamma-trityl-l-glutamine n-alpha-fmoc-n-trityl-l-glutamine N(alpha)-fmoc-N(delta)-trityl-L-glutamine na-fmoc-N-delta-trityl-L-glutamine Fmoc-L-Glutamine(Trityl) N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine D-Glutamine,N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)- N-Fmoc-N'-trityl-L-glutamine Fmoc-L-Gln(Trt)-OH

Molecular Formula: C39H34N2O5

Molecular Weight: 610.7

MDL Number: MFCD00077056

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

Nalpha-Fmoc-Ndelta-trityl-L-glutamine is a protected derivative of L-glutamine, featuring a 9-fluorenylmethoxycarbonyl (Fmoc) group at the alpha-amino position and a trityl (Trt) group at the delta-amide nitrogen. This orthogonal protection strategy allows for selective deprotection during solid-phase peptide synthesis (SPPS), where Fmoc is removed under basic conditions and Trt under mild acidic conditions. It is primarily utilized as a key building block in the synthesis of peptides and peptidomimetics, particularly for incorporating glutamine residues without side-chain interference. The compound is essential in pharmaceutical research for constructing bioactive peptides, including those targeting neurological, metabolic, and oncological pathways. Its high purity and stability make it a standard reagent in both academic and industrial peptide chemistry. Additionally, it serves as a precursor for drug discovery intermediates, enabling the development of peptide-based therapeutics and diagnostic agents. The compound is typically stored at -20буC to maintain integrity and is widely available from specialized chemical suppliers.

Physical Properties

Melting Point: 165-172 °C

Boiling Point: 873.5 °C at 760 mmHg

Flash Point: 482.1 °C

Density: 1.257 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white to light yellow crystal powder