3-(Benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate, CAS No. 132-17-2

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132-17-2

Catalog No. EBD49028

CAS 132-17-2

Name 3-(Benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate

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Basic Information

Synonyms: benztropinemethanesulfonate benzatropinemesilate 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octanemethanesulfonate(1:1) 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octanesulfate (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octanemethanesulfonate(1:1) cogentin cogentinol benzotropinemesylate benztropinemesylate 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octanemethanesulfonate 3-(diphenylmethoxy)-8-azabicyclo(3.2.1)octanendo-8-azabicyclo(3.2.1)octanmethanesulfonate 3-alpha-(diphenylmethoxy)-1-alpha-h,5-alpha-h-tropanemethanesulfonate 3-(Benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octanemethanesulfonate

Molecular Formula: C22H29NO4S

Molecular Weight: 403.53

MDL Number: MFCD00074784

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > APIs and Their Salts > Anesthetics and Analgesics

Product Description:

Benzatropine mesylate is the mesylate salt of benzatropine, a synthetic compound with both anticholinergic and antihistaminic properties. It is a white, crystalline powder that is soluble in water and alcohol. Benzatropine mesylate is primarily used as an active pharmaceutical ingredient (API) in the treatment of Parkinson's disease and drug-induced extrapyramidal symptoms (EPS). It functions as a centrally acting anticholinergic agent, blocking muscarinic acetylcholine receptors in the brain to help restore the balance between dopamine and acetylcholine. This makes it effective in managing symptoms like tremor, rigidity, and sialorrhea. It is also used as an adjunct therapy in some cases of dystonia. While its primary use is therapeutic, benztropine and its derivatives have also been investigated in pharmacological research for their potential effects on dopamine transport. As a prescription drug, it is associated with typical anticholinergic side effects such as dry mouth, blurred vision, and constipation, and requires medical supervision for use.

Physical Properties

Color: white to beige

Melting Point: 135 °C(lit.)

Boiling Point: 547.8 °C at 760 mmHg

Flash Point: 285.1 °C

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2811

Analytical Data

Appearance: White to off-white solid