(R,R)-(-)-2,2'-Isopropylidenebis(4-tert-butyl-2-oxazoline), CAS No. 131833-97-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

131833-97-1

Catalog No. EBD41086

CAS 131833-97-1

Name (R,R)-(-)-2,2'-Isopropylidenebis(4-tert-butyl-2-oxazoline)

Get Quote

Basic Information

Synonyms: (R,R)-(-)-2,2'-Isopropylidenebis(4-tert-butyl-2-oxazoline) (R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) (4R,4'R)-2,2'-propane-2,2-diylbis(4-tert-butyl-4,5-dihydro-1,3-oxazole) (r,r)-(+)-2,2-isopropylidenebis(4-tert-butyl-2-oxazolin (r,r)-(-)-2,2’-isopropylideneboxazoline) (4r,4'r)-2,2'-(1-methylethylidene)bis[4-(1,1-dimethylethyl)-4,5-dihydro-oxazole (4r,4'r)-2,2'-(propane-2,2-diyl)bis(4-(tert-butyl)-4,5-dihydrooxazole)

Molecular Formula: C17H30N2O2

Molecular Weight: 294.43

MDL Number: MFCD07368371

Categories: Synthetic Chemistry > Catalysts and Ligands > Nitrogen Ligands Synthetic Chemistry > Catalysts and Ligands > Chiral Ligands

Product Description:

(R,R)-(-)-2,2'-Isopropylidenebis(4-tert-butyl-2-oxazoline) is a chiral bis(oxazoline) ligand, commonly abbreviated as (R,R)-tBu-BOX. Structurally, it features two oxazoline rings connected via a quaternary carbon center, with tert-butyl groups providing steric bulk and the isopropylidene bridge enforcing a rigid, C2-symmetric chiral environment. This compound is primarily utilized as a privileged chiral ligand in asymmetric catalysis. It forms stable complexes with a variety of transition metals, including copper, zinc, and palladium, to catalyze enantioselective reactions such as cyclopropanation, Diels-Alder reactions, and aldol condensations. The C2-symmetry and tunable steric properties of the tert-butyl groups are critical for achieving high enantioselectivity. As a nitrogen-donor ligand, it is a cornerstone in the field of asymmetric synthesis, particularly for academic research and the development of enantiopure pharmaceutical intermediates. Its high purity and defined stereochemistry make it a standard tool for chemists requiring precise chiral induction.

Physical Properties

Boiling Point: 350.424°C at 760 mmHg

Flash Point: 134.912°C

Density: 1.048g/cm3