2-(Trifluoromethyl)isonicotinic acid, CAS No. 131747-41-6

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

131747-41-6

Catalog No. EBD28272

CAS 131747-41-6

Name 2-(Trifluoromethyl)isonicotinic acid

Get Quote

Basic Information

Synonyms: 2-Trifluoromethyl-isonicotinicacid 2-(Trifluoromethyl)isonicotinicacid 2-(trifluoromethyl)pyridine-4-carboxylicacid 2-(trifluoromethyl)isonicotinicacid97% 2-trifluoromethyl-4-pyridinecarboxylicacid 2-(trifluoromethyl)pyridin-4-carboxylicacid 4-pyridinecarboxylicacid,2-(trifluoromethyl)- 2-(trifluoromethyl)pyridine-4-carboxylicacid,4-carboxy-2-(trifluoromethyl)pyridine 2-Pyridinecarboxylicacid,6-(trifluoromethyl)- 6-(Trifluoromethyl)-2-pyridinecarboxylicacid 6-(Trifluoromethyl)pyridine-2-carboxylicacid 6-Trifluoromethylpyridine-2-carboxylicacid 2-(trifluoromethyl)-4-Pyridinecarboxylicacid

Molecular Formula: C7H4F3NO2

Molecular Weight: 191.11

MDL Number: MFCD07774132

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

2-(Trifluoromethyl)isonicotinic acid is a heterocyclic organic compound featuring a pyridine ring substituted with a carboxylic acid group and a trifluoromethyl group at the 2-position. This structure combines the aromatic nitrogen of isonicotinic acid with the strong electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. This compound is primarily utilized as a key pharmaceutical intermediate. Its most notable application is in the synthesis of novel antibacterial agents, particularly fluoroquinolone derivatives. The trifluoromethyl-substituted pyridine moiety serves as a crucial structural component in the development of these drugs, contributing to improved pharmacokinetic properties and target binding affinity. It is also employed in medicinal chemistry research for constructing bioactive molecules targeting various diseases. As a bifunctional building block containing both a carboxylic acid and a heteroaromatic ring, it is valuable in organic synthesis for constructing complex molecular architectures. The carboxylic acid group allows for amide bond formation or esterification, facilitating its incorporation into larger molecules.

Physical Properties

Melting Point: 217-223 °C

Boiling Point: 338.881 °C at 760 mmHg

Flash Point: 158.75 °C

Density: 1.485 g/cm3