N-Cbz-Nortropinone, CAS No. 130753-13-8

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130753-13-8

Catalog No. EBD44127

CAS 130753-13-8

Name N-Cbz-Nortropinone

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Basic Information

Synonyms: N-Cbz-Notropinone Benzyl3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate N-Benzyloxycarbonylnortropinone benzyl(1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 3-Oxo-8-Aza-Bicyclo[3.2.1]Octane-8-CarboxylicAcidBenzylEster n-cbz-4-nortropinone n-cbz-nortropinone,97% 8-cbz-3-oxo-8-azabicyclo[3.2.1]octane N-Cbz-Nortropinone

Molecular Formula: C15H17NO3

Molecular Weight: 259.3

MDL Number: MFCD07776632

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Carbobenzyloxynortropinone is a bicyclic organic compound featuring a nortropinone (8-azabicyclo[3.2.1]octan-3-one) core structure with a carbobenzyloxy (Cbz) protecting group attached to the nitrogen atom. This specific derivative combines the characteristic tropane alkaloid skeleton with a widely used amine-protecting group. Its primary application is as a key synthetic intermediate in medicinal chemistry, particularly for the preparation of novel tropane alkaloid derivatives and analogs. The Cbz-protected nortropinone serves as a versatile precursor for further functionalization at the amine or carbonyl positions, enabling the exploration of structure-activity relationships in drug discovery programs targeting the central nervous system. While not a final active pharmaceutical ingredient itself, this compound is a valuable building block for researchers developing potential therapeutic agents, such as ligands for neurotransmitter transporters or receptors. Its synthesis and use are documented in specialized chemical literature and patent applications related to pharmaceutical research.

Physical Properties

Boiling Point: 415.7 °C at 760 mmHg

Flash Point: 205.2 °C

Density: 1.241 g/cm3