L-Glutamic acid alpha-benzyl ester, CAS No. 13030-09-6

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13030-09-6

Catalog No. EBD29495

CAS 13030-09-6

Name L-Glutamic acid alpha-benzyl ester

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Basic Information

Synonyms: L-Glu-a-O-Bzl Glu.OBzl (4S)-4-ammonio-5-(benzyloxy)-5-oxopentanoate L-GlutamicAcidAlpha-BenzylEster H-Glu-OBzl·HCl a-benzyl-l-glutamate l-alpha-benzylglutamate glutamicacid-obzl 1-benzyll-glutamate l-glutamicacid1-benzylester h-l-glu-obzl H-Glu-OBzl

Molecular Formula: C12H15NO4

Molecular Weight: 237.25

MDL Number: MFCD00037312

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

H-Glu-OBzl, also known as L-Glutamic acid 5-benzyl ester, is a protected derivative of the amino acid L-glutamic acid. Its chemical structure features a benzyl ester group protecting the side-chain carboxylic acid, while the alpha-amino group remains free. This specific protection pattern makes it a valuable building block in peptide synthesis, particularly for introducing glutamic acid residues where the side chain needs to be selectively deprotected later. The primary application of H-Glu-OBzl is as a key intermediate in the solid-phase and solution-phase synthesis of peptides and peptidomimetics. It is extensively used in research and development for creating bioactive peptides, including those with potential therapeutic applications in areas such as oncology and immunology. Its role is crucial for constructing peptide sequences that require precise control over the glutamic acid side chain's reactivity. As a protected amino acid derivative, it is a staple reagent in bioconjugation chemistry and the preparation of complex molecular architectures. It is commercially available from major suppliers of fine chemicals and peptide synthesis reagents for research use.

Physical Properties

Melting Point: 157 °C

Boiling Point: 416 °C at 760 mmHg

Flash Point: 205.4 °C

Density: 1.245 g/cm3

Storage: -15°C