4-Trifluoromethylphenylboronic acid, CAS No. 128796-39-4

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128796-39-4

Catalog No. EBD435387

CAS 128796-39-4

Name 4-Trifluoromethylphenylboronic acid

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Basic Information

Synonyms: 4-Trifluoromethylphenylboronicacid p-(trifluoromethyl)phenylboronicacid rarechemahpb0095 4-(trifluoromethyl)phenylboronicacid 4-(trifluoromethyl)benzeneboronicacid alpha,alpha,alpha-trifluoro-p-tolueneboronicacid alpha,alpha,alpha-trifluoro-p-tolylboronicacid akosbrn-0049 α,α,α-trifluoro-p-tolylboronicacid 4-[(Trifluoromethyl)-Phenyl]-BoronicAcid 4-boronobenzotrifluoride 4-trifluoromethylboronicacid -trifluoro-p-tolylboronicacid 4-(trifluoromethyl)phenylboricacid 4-tirfluromethylphenylboronicacid 4-(trifluuoromethyl)phenylboronicacid

Molecular Formula: C7H6BF3O2

Molecular Weight: 189.93

MDL Number: MFCD00151855

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Materials Chemistry > Optoelectronic and Organic Semiconductor Materials > OLED and Organic Optoelectronic Precursors

Product Description:

4-Trifluoromethylphenylboronic acid is an organoboron compound featuring a phenyl ring substituted with a trifluoromethyl group at the para position and a boronic acid moiety. It is a white to off-white crystalline solid, stable under normal conditions, and widely used as a key building block in organic synthesis. This compound is primarily employed as a boronic acid coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds to construct biaryl structures. The electron-withdrawing trifluoromethyl group enhances the reactivity and selectivity in these transformations. It is extensively utilized in the synthesis of pharmaceutical intermediates, agrochemicals, and advanced materials, particularly for developing drug candidates targeting neurological disorders, anti-inflammatory agents, and kinase inhibitors. Additionally, 4-Trifluoromethylphenylboronic acid serves as a precursor for functionalized arenes and can be used in the preparation of fluorescent probes or sensor materials due to its unique electronic properties. It is typically stored under inert atmosphere and handled with standard precautions for boronic acids.

Physical Properties

Melting Point: 245-250 °C(lit.)

Boiling Point: 258.6 °C at 760 mmHg

Flash Point: 110.2 °C

Density: 1.36 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: white powder