N-4-Boc-2-piperazinecarboxylic acid, CAS No. 128019-59-0

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128019-59-0

Catalog No. EBD2202838

CAS 128019-59-0

Name N-4-Boc-2-piperazinecarboxylic acid

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Basic Information

Synonyms: 1,3-Piperazinedicarboxylicacid,1-(1,1-dimethylethyl)ester N-4-Boc-2-piperazinecarboxylicacid 4-(tert-butoxylcarbonyl)-piperazine-2-carboxylicacid 4-n-boc-piperazine-2-carboxylicacid 4-BOC-PIPERAZINE-2-(+/-)CARBOXYLIC-ACID 4-(2,2-dimethylpropanoyloxy)piperazine-2-carboxylicacid 4-N-Boc-2-piperazinecarboxylicacid

Molecular Formula: C10H18N2O4

Molecular Weight: 230.26

MDL Number: MFCD01076218

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-Boc-piperazine-2-carboxylic acid is a heterocyclic organic compound featuring a piperazine ring core. The molecule contains both a carboxylic acid group and a tert-butoxycarbonyl (Boc) protected secondary amine, making it a versatile bifunctional building block. It is a white to off-white crystalline powder. This compound is primarily employed as a key intermediate in pharmaceutical synthesis. The Boc-protected amine allows for selective deprotection and further functionalization, while the carboxylic acid group facilitates amide bond formation. It is notably used in the synthesis of various drug candidates, including kinase inhibitors and other bioactive molecules targeting diverse therapeutic areas. As a protected amino acid derivative, it serves as a crucial chiral or achiral scaffold for constructing complex molecular architectures in medicinal chemistry. Its stability and well-defined reactivity profile make it a valuable reagent in parallel synthesis and combinatorial chemistry for drug discovery programs.

Physical Properties

Melting Point: 231-239 °C

Boiling Point: 371.8 °C at 760 mmHg

Flash Point: 178.6 °C

Density: 1.193 g/cm3