3alpha-hydroxy-5beta-pregnan-20-one, CAS No. 128-20-1

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128-20-1

Catalog No. EBD2638086

CAS 128-20-1

Name 3alpha-hydroxy-5beta-pregnan-20-one

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Basic Information

Synonyms: eltanolone 3alpha-hydroxy-5beta-pregnan-20-one 3alpha,5beta-epimericpregnanolone 3alpha,5beta-pregnanolone 3-alpha-hydroxy-5-beta-pregnan-20-on 5beta-pregnan-20-one,3alpha-hydroxy- 5-pregnan-3-ol-20-one pregnan-20-one,3-hydroxy-,(3alpha,5beta)- pregnan-3alpha-ol-20-one pregnanoloneii 5B-pregnan-3A-ol-20-one 3-alpha-hydroxy-5-beta-pregnan-20-one 3alpha-Hydroxy-5beta-tetrahydroprogesterone (3alpha,5beta)-3-hydroxypregnan-20-one 3-hydroxypregnan-20-one (3alpha)-3-hydroxypregnan-20-one

Molecular Formula: C21H34O2

Molecular Weight: 318.49

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Pregnanolone, also known as 3α-hydroxy-5β-pregnan-20-one, is a naturally occurring neurosteroid metabolite of progesterone. It is a potent positive allosteric modulator of the GABA_A receptor, acting primarily at synaptic and extrasynaptic receptors containing δ subunits. Its primary application is in neuroscience research as a key endogenous modulator of inhibitory neurotransmission. Pregnanolone is studied for its role in various physiological and pathophysiological processes, including stress response, mood regulation, sleep, and neuroprotection. It serves as a reference standard and a crucial tool for investigating the mechanisms of neurosteroid action and their potential therapeutic implications in conditions like anxiety, depression, and epilepsy. While it is a natural product, its use is predominantly confined to research settings. It is not widely marketed as a therapeutic agent itself but is fundamental for understanding the neurosteroid pathway and for the development of synthetic neuroactive steroids.

Physical Properties

Melting Point: 149 °C

Boiling Point: 431.2 °C at 760 mmHg

Flash Point: 183.9 °C

Density: 1.053g/cm3