(S)-1-[3,5-Bis(trifluoromethyl)phenyl)ethylamine, CAS No. 127733-40-8

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127733-40-8

Catalog No. EBD29343

CAS 127733-40-8

Name (S)-1-[3,5-Bis(trifluoromethyl)phenyl)ethylamine

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Basic Information

Synonyms: (S)-1-[3,5-Bis(trifluoromethyl)phenyl)ethylamine (s)-alpha-methyl-bis-3,5-trifluoromethylbenzylamine s-mbt-pem (s)-1-(3,5-bis(trifluoromethyl)phenyl)ethanamine (s)-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine (s)-1-[bis-3,5-(trifluoromethyl)phenyl]ethylamine (r)-1-[3,5-bis(trifluoromethyl)phenyl]ethylaminehcl benzenemethanamine,α-methyl-3,5-bis(trifluoromethyl)-,(αs)- (r)-1-(3,5-bis(trifluoromethyl)phenyl)ethanaminehydrochloride (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanamine [(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]ammoniumchloride (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]E

Molecular Formula: C10H9F6N

Molecular Weight: 257.18

MDL Number: MFCD03093013

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine is a chiral amine derivative characterized by a 3,5-bis(trifluoromethyl)phenyl group attached to the chiral center. The presence of the strongly electron-withdrawing trifluoromethyl groups significantly influences its electronic properties and lipophilicity. This compound is a key chiral building block in pharmaceutical synthesis. Its primary application is as a crucial intermediate in the production of neurokinin-1 (NK1) receptor antagonists, most notably for the synthesis of Aprepitant and its prodrug Fosaprepitant, which are antiemetic drugs used to prevent chemotherapy-induced nausea and vomiting. The (S)-enantiomer is essential for the desired biological activity. As a chiral amine with a unique aromatic substitution pattern, it is also employed in asymmetric synthesis and as a precursor for other bioactive molecules. It is typically handled under inert atmosphere due to its sensitivity and requires standard safety precautions for amine compounds.

Physical Properties

Boiling Point: 60/14mm

Flash Point: 66.334 °C

Density: 1.328 g/cm3