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    1273579-40-0

    Catalog No. EBD3724308

    CAS 1273579-40-0

    Name (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-Benzopyran-3-carboxamide

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    Basic Information

    Synonyms: Chroman 1 

    Molecular Formula: C24H28N4O4

    Molecular Weight: 436.5

    Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    The compound with CAS number 1273579-40-0, known as (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide, is a synthetic small molecule. It is a key intermediate in the synthesis of GDC-0077 (Inavolisib), a potent and selective PI3Kα inhibitor developed for the treatment of PIK3CA-mutant breast cancer. This compound is a crucial building block in the final synthetic steps of GDC-0077. Its structure incorporates a chroman-3-carboxamide core linked to a dimethylaminoethoxy-substituted phenyl ring bearing a pyrazole group. This specific molecular architecture is essential for conferring high selectivity and potency against the PI3Kα isoform, a critical target in oncology. As a high-value pharmaceutical intermediate, its primary application is strictly within the research, development, and manufacturing of the investigational drug Inavolisib. It is not a general-purpose synthetic reagent and is handled under controlled conditions specific to active pharmaceutical ingredient (API) production.
    Physical Properties
    mg g kg ml l t