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    127199-44-4

    Catalog No. EBD8271

    CAS 127199-44-4

    Name (R)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane

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    Basic Information

    Synonyms: Carbamicacid,(7R)-5-azaspiro[2.4]hept-7-yl-,1,1-dimethylethylester (R)-tert-butyl5-azaspiro[2.4]heptan-7-ylcarbamate carbamicacid,(7r)-5-azaspiro[2.4]hept-7-yl-,1,1-dimethylethylester(9ci) n-(7r)-5-azaspiro[2.4]hept-7-yl-carbamicacid1,1-dimethylethylester tert-butyln-[(7r)-5-azaspiro[2.4]heptan-7-yl]carbamate (R)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane

    Molecular Formula: C11H20N2O2

    Molecular Weight: 212.29

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-(7R)-5-Azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester is a chiral, bicyclic amine derivative featuring a spirocyclic structure. It serves as a key chiral building block and advanced pharmaceutical intermediate. The compound contains a protected primary amine (as a Boc carbamate) and a secondary amine within the azaspiro[2.4]heptane scaffold. Its primary application is in the synthesis of complex drug candidates. The rigid spirocyclic framework and defined stereochemistry make it valuable for constructing molecules with specific three-dimensional shapes, which is crucial in modern medicinal chemistry for optimizing drug-target interactions and pharmacokinetic properties. It is particularly relevant in the development of central nervous system (CNS) active agents and other therapeutic compounds where conformational restriction is desired. As a Boc-protected amine, it is a versatile intermediate that can be readily deprotected and further functionalized. Its use is documented in patent literature and research focused on novel therapeutic agents, highlighting its role in facilitating efficient synthetic routes to pharmacologically active molecules.
    Physical Properties

    Boiling Point: 329.029 °C at 760 mmHg

    Flash Point: 152.791 °C

    Density: 1.099g/cm3

    mg g kg ml l t