4-[(2,4- Dimethoxyphenyl)(Fmocamino) methyl]phenoxyacetic acid, CAS No. 126828-35-1

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126828-35-1

Catalog No. EBD2857021

CAS 126828-35-1

Name 4-[(2,4- Dimethoxyphenyl)(Fmocamino) methyl]phenoxyacetic acid

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Basic Information

Synonyms: 4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic acid rinkamidereagent n-alpha-(9-fluorenylmethoxycarbonyl)-2,4-dimethoxy-4'-(carboxymethyloxy)-benzhydrylamine n-fmoc-(2,4-dimethoxyphenyl)aminomethylphenoxyaceticacid p-[(r,s)-a-[1-(9h-fluoren-9-yl)-methoxyformamido]-2,4-dimethoxybenzyl]-phenoxyaceticacid p-((r,s)-alpha-[1-(9h-flouren-9-yl)-methoxyformamido]-2,4-dimethoxybenzyl)-phenoxyaceticacid p-((r,s)-alpha-[1-(9h-fluoren-9-yl)-methoxyformamido]-2,4-dimethoxybenzyl)-phenoxyaceticacid 4-(r,s)-a-[1-(9h-fluoren-9-yl)-methoxy-formamido]-2,4-dimethoxybenzyl-phenoxyacetic-acid 4'-[(r,s)-alpha-[1-(9-fluorenyl)methoxycarbonylamino]-2,4-dimethoxybenzyl]-phenol rinkamidelinker 4-[(2,4-Dimethoxyphenyl)(Fmocamino)methyl]phenoxyaceticacid Fmoc-2,4-dimethoxy-4'-(carboxymethyloxy)-benzhydrylamine

Molecular Formula: C32H29NO7

Molecular Weight: 539.58

Categories: Materials Chemistry > Polymers and Macromolecular Materials > Polymer Additives Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

4-[(2,4-Dimethoxyphenyl)(Fmocamino)methyl]phenoxyacetic acid is a specialized building block featuring a Fmoc-protected amino group and a phenoxyacetic acid moiety, with a 2,4-dimethoxyphenyl substituent. Its molecular structure integrates a protected amine, an aromatic ether, and a carboxylic acid functional group, making it a versatile intermediate for solid-phase peptide synthesis (SPPS) and combinatorial chemistry. This compound is primarily utilized as a linker or handle in the synthesis of peptide-based therapeutics and peptidomimetics, particularly in the construction of cyclic peptides or modified peptide sequences. The Fmoc group enables orthogonal deprotection under mild basic conditions, while the phenoxyacetic acid unit serves as a stable attachment point for resin or further conjugation. It is also employed in the development of targeted drug delivery systems and bioactive molecule libraries. Due to its role in constructing complex peptide architectures, it is classified under both pharmaceutical intermediates and peptide-related biochemical reagents. Its application is highly specific to medicinal chemistry and drug discovery, rather than general synthetic chemistry.

Physical Properties

Melting Point: ~180 °C (dec.)