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    126496-81-9

    Catalog No. EBD3333156

    CAS 126496-81-9

    Name N-[(phenylmethoxy)carbonyl]-D-Tryptophan, phenylmethyl ester

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    Basic Information

    Synonyms: N-[(phenylmethoxy)carbonyl]-D-Tryptophan,phenylmethylester Z-D-Trp-OBzl

    Molecular Formula: C26H24N2O4

    Molecular Weight: 428.48

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

    Product Description:
    N-Carbobenzoxy-D-tryptophan benzyl ester is a protected derivative of the essential amino acid D-tryptophan. It features two key protecting groups: the N-terminal amine is protected by a carbobenzoxy (Cbz or Z) group, and the carboxylic acid is protected as a benzyl (Bzl or OBzl) ester. This specific configuration renders it a chiral, protected amino acid building block. Its primary and well-defined application is in the field of peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) and solution-phase methods for research and pharmaceutical development. The D-tryptophan residue is crucial for introducing specific conformational and biological properties into synthetic peptides. The Cbz group can be removed under mild hydrogenolytic conditions, while the benzyl ester offers orthogonal deprotection strategies, making it a versatile intermediate for constructing complex peptide sequences. This compound is a specialized reagent used in the synthesis of peptide-based drug candidates, bioactive peptides, and for studying structure-activity relationships. It is not a commodity chemical but a high-value intermediate for targeted research in medicinal chemistry and biochemistry.
    Physical Properties
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