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    1263205-96-4

    Catalog No. EBD4026310

    CAS 1263205-96-4

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    Basic Information

    Molecular Formula: C20H21F6N3O2

    Molecular Weight: 449.4

    Categories: Medicinal Chemistry > Targeted Protein Degradation Tools > Ligand-Linker Conjugates Medicinal Chemistry > Targeted Protein Degradation Tools > Target Protein Ligands

    Product Description:
    This compound, with CAS number 1263205-96-4, is a chemical structure featuring a 3-cyclobutene-1,2-dione core substituted with a 3,5-bis(trifluoromethyl)phenylamino group and a ((1S,2S)-2-(dimethylamino)cyclohexyl)amino group. It is a key intermediate or a direct component in the development of targeted protein degraders, specifically Proteolysis-Targeting Chimeras (PROTACs). Its primary application is in medicinal chemistry research for targeted protein degradation. The structure incorporates elements designed to bind to specific target proteins (via the substituted phenyl group) and to E3 ubiquitin ligases (via the chiral cyclohexylamine moiety), linked through the central dione scaffold which can serve as or be part of the linker. This makes it a valuable tool for constructing PROTAC molecules aimed at degrading disease-relevant proteins. As a research-grade chemical, it is used in early-stage drug discovery to explore and optimize PROTAC efficacy and selectivity. Handling requires standard laboratory safety precautions for organic compounds.
    Physical Properties
    mg g kg ml l t