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    1260763-03-8

    Catalog No. EBD2925421

    CAS 1260763-03-8

    Name 5'-Bromospiro[cyclopropane-1,3'-indoline]

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    Basic Information

    Synonyms: 5'-Bromospiro[cyclopropane-1,3'-indoline]

    Molecular Formula: C10H10BrN

    Molecular Weight: 224.1

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Spiro Compounds

    Product Description:
    5'-Bromospiro[cyclopropane-1,3'-indoline] is a specialized organic compound featuring a spirocyclic structure that combines a cyclopropane ring and an indoline moiety. This unique architecture, particularly the presence of the bromine atom at the 5' position, makes it a valuable and versatile building block in synthetic chemistry. Its primary application is in pharmaceutical research and development as a key intermediate. The spirocyclic indoline scaffold is a privileged structure found in numerous bioactive molecules and drug candidates. This specific brominated derivative serves as a crucial precursor for the synthesis of more complex spirocyclic compounds, especially through cross-coupling reactions like Suzuki or Buchwald-Hartwig amination, enabling rapid diversification for structure-activity relationship (SAR) studies. It is instrumental in constructing core frameworks for potential therapeutic agents. Due to its defined reactive handle (bromine) and complex, three-dimensional spirocyclic core, it is also categorized as a high-value organic synthesis building block, specifically within the class of spirocyclic compounds. It is not a commodity chemical but a research-grade material used primarily in medicinal chemistry to explore new chemical space for drug discovery.
    Physical Properties
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