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    1257856-86-2

    Catalog No. EBD2219016

    CAS 1257856-86-2

    Name (S)-N-Boc-3-Cyanomorpholine

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    Basic Information

    Molecular Formula: C10H16N2O3

    Molecular Weight: 212.25

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    (S)-N-Boc-3-Cyanomorpholine is a chiral morpholine derivative featuring a cyano group at the 3-position and a tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom. This compound is a high-purity building block with defined stereochemistry, commonly supplied as a white to off-white solid. Its primary application is as a key chiral intermediate in pharmaceutical research and development. The morpholine scaffold is a privileged structure in medicinal chemistry, and the presence of the cyano group provides a versatile handle for further chemical transformations, such as reduction to amines or conversion to other functional groups like tetrazoles. This specific enantiomer is particularly valuable for the synthesis of targeted bioactive molecules, including potential protease inhibitors and other therapeutic agents where stereochemistry is critical for activity. As a specialized synthon, it is not a commodity chemical but is utilized in discovery and process chemistry for constructing complex molecular architectures. Its Boc-protected amine ensures compatibility with a wide range of synthetic conditions, making it a valuable tool for multi-step syntheses in drug discovery programs.
    Physical Properties

    Boiling Point: 340.3 °C at 760 mmHg

    Flash Point: 159.6 °C

    Density: 1.13 g/cm3

    mg g kg ml l t