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    1257648-78-4

    Catalog No. EBD4038430

    CAS 1257648-78-4

    Name 4-[(3-(1H-Imidazol-1-yl)propyl)aminomethyl]phenylboronic acid pinacol ester

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    Basic Information

    Synonyms: 4-[3-(1-Imidazolyl)propylaminomethyl]benzeneboronicacidpinacolester

    Molecular Formula: C19H28BN3O2

    Molecular Weight: 341.26

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Targeted Protein Degradation Tools > Linkers

    Product Description:
    3-(1H-Imidazol-1-yl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine is a bifunctional organic compound featuring an imidazole group and a pinacol boronate ester group, connected by a flexible propylamine linker. This structure makes it a versatile building block in medicinal chemistry and chemical biology. Its primary application is in the development of targeted protein degraders, such as Proteolysis-Targeting Chimeras (PROTACs). The imidazole moiety can serve as a ligand for certain target proteins (e.g., those with metal-binding sites), while the boronic acid pinacol ester is a crucial functional group for Suzuki-Miyaura cross-coupling reactions, enabling its conjugation to E3 ligase ligands or other molecular scaffolds. Therefore, it functions as a key "linker" component in PROTAC design, connecting the warhead (target binder) and the recruiter (E3 ligase binder). As a specialized intermediate, it is not a common, general-purpose synthetic reagent. Its value lies in its application-specific design for constructing complex bifunctional molecules in drug discovery, particularly in the rapidly evolving field of targeted protein degradation.
    Physical Properties
    mg g kg ml l t