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    1256667-56-7

    Catalog No. EBD2925954

    CAS 1256667-56-7

    Name (3R)-1-(OXETAN-3-YL)PYRROLIDIN-3-AMINE

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    Basic Information

    Molecular Formula: C7H14N2O

    Molecular Weight: 142.2

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Targeted Protein Degradation Tools > Linkers

    Product Description:
    (3R)-1-(Oxetan-3-yl)pyrrolidin-3-amine is a chiral amine compound featuring a pyrrolidine ring substituted with an oxetane group. It serves as a key synthetic intermediate and building block in medicinal chemistry, particularly valued for its rigid, three-dimensional structure and the presence of a basic amine functional group. Its primary application is in the research and development of targeted protein degraders, such as Proteolysis-Targeting Chimeras (PROTACs). In this context, the molecule is frequently utilized as a component of the linker that connects the E3 ligase ligand to the target protein ligand. The oxetane ring is known to improve physicochemical properties like metabolic stability and solubility, while the pyrrolidine amine provides a handle for further chemical conjugation. This compound is a specialized reagent in the field of chemical biology and drug discovery, specifically for constructing novel bifunctional degraders. It is not a commodity chemical and is typically used in research-scale synthesis for investigating new therapeutic modalities.
    Physical Properties
    mg g kg ml l t