Rotigotine hydrochloride, CAS No. 125572-93-2

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125572-93-2

Catalog No. EBD39283

CAS 125572-93-2

Name Rotigotine hydrochloride

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Basic Information

Synonyms: (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-olhydrochloride (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-olhydrochloride RotigotineHydrochloride (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenolhydrochloride

Molecular Formula: C19H26ClNOS

Molecular Weight: 351.93

MDL Number: MFCD00906149

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Rotigotine hydrochloride is the hydrochloride salt of rotigotine, a non-ergoline dopamine agonist. It is a synthetic compound structurally related to dopamine, featuring a naphthothiophene moiety. This compound is the active pharmaceutical ingredient (API) in a transdermal patch formulation used for the treatment of Parkinson's disease and moderate-to-severe restless legs syndrome. It acts by stimulating dopamine receptors (D1, D2, and D3) in the brain, compensating for the dopamine deficiency characteristic of Parkinson's disease. The transdermal delivery system provides continuous drug release over 24 hours, helping to maintain stable plasma levels and reduce motor fluctuations. Rotigotine hydrochloride is a critical component in the manufacturing of this specific therapeutic product.

Physical Properties

Boiling Point: 470.1 °C at 760 mmHg

Flash Point: 238.1 °C

Analytical Data

Appearance: Almost white to white crystalline powder