Hydrocortisone sodium succinate, CAS No. 125-04-2

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125-04-2

Catalog No. EBD39275

CAS 125-04-2

Name Hydrocortisone sodium succinate

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Basic Information

Synonyms: hydrocortisonehemisuccinatesodiumsalt hydrocortisone-hydrogensuccinatesodiumsalt hydrocortisone21-hemisuccinatesodium hydrocortisone21-hemisuccinatesodiumsalt cortisol21-hemisuccinatesod cortisol21-hemisuccinatesodium-potassiumsalt cortisol21-hemisuccinatesodiumsalt HydrocortisoneSodiumSuccinate Hydrocortisone-21-sodiumSuccinate HydorcortisoneSodiumSuccinate sodium4-[(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoate sodium4-{[(11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoate 11b,17a,21-Trihydroxy-4-pregnene-3,20-dione21-hemisuccinatesodiumsalt

Molecular Formula: C25H34NaO8

Molecular Weight: 485.52

MDL Number: MFCD00046256

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > APIs and Their Salts > Immuno-modulators and Anti-inflammatory Drugs

Product Description:

Hydrocortisone sodium succinate is the sodium salt of the hemisuccinate ester of hydrocortisone (cortisol). It is a white or almost white, hygroscopic, amorphous powder that is freely soluble in water and alcohol. This chemical modification significantly enhances the water solubility of the parent corticosteroid, making it suitable for parenteral administration. This compound is a synthetic glucocorticoid used primarily as an anti-inflammatory and immunosuppressive agent. Its main applications include the emergency treatment of severe allergic reactions, adrenal insufficiency (Addisonian crisis), shock, and acute exacerbations of inflammatory conditions. It exerts its effects by binding to glucocorticoid receptors, modulating gene expression to inhibit the synthesis of pro-inflammatory mediators. Due to its rapid onset of action when administered intravenously or intramuscularly, it is a critical agent in hospital emergency and intensive care settings. It is also used in some chemotherapy regimens to manage side effects. As a salt of a steroid API, it is classified as a finished pharmaceutical ingredient for injectable formulations.

Physical Properties

Boiling Point: 685.5 °C at 760 mmHg

Flash Point: 231.1 °C

Solubility: H2O: 50 mg/mL

Storage: −20°C