[(1S,4R)-4-(2,6-diaminopurin-9-yl)cyclopent-2-en-1-yl]methanol, CAS No. 124752-25-6

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124752-25-6

Catalog No. EBD112643

CAS 124752-25-6

Name [(1S,4R)-4-(2,6-diaminopurin-9-yl)cyclopent-2-en-1-yl]methanol

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Basic Information

Synonyms: [(1S,4R)-4-(2,6-diaminopurin-9-yl)cyclopent-2-en-1-yl]methanol 6-aminocarbovir 2-Cyclopentene-1-methanol,4-(2,6-diamino-9H-purin-9-yl)-,(1S-cis)- [(1S,4R)-4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol

Molecular Formula: C11H14N6O

Molecular Weight: 246.27

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > Drug Impurities and Reference Standards > Process-Related Standards

Product Description:

The compound with CAS number 124752-25-6 is known as Descyclopropyl Abacavir. It is a key intermediate and a major process-related impurity in the synthesis of Abacavir, a potent nucleoside reverse transcriptase inhibitor (NRTI) used in the treatment of HIV-1 infection. Its structure is closely related to the final active pharmaceutical ingredient (API), differing by the absence of the cyclopropyl group attached to the purine ring. As a synthetic intermediate, its primary role is in the manufacturing process of Abacavir sulfate. More critically, it is monitored and controlled as a specified impurity in the final drug substance according to regulatory guidelines (e.g., ICH Q3A). Analytical reference standards of Descyclopropyl Abacavir are essential for quality control, ensuring the purity, safety, and efficacy of the antiviral medication Abacavir.

Physical Properties

Boiling Point: 628.2°Cat760mmHg

Flash Point: 333.7°C

Density: 1.75g/cm3