N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S,2S)-2-(1-piperidinyl)cyclohexyl]thiourea is a potent and selective small-molecule ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase. It is a key component in the design of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) modalities. The compound features a (1S,2S)-2-(piperidin-1-yl)cyclohexylamine moiety, which serves as the high-affinity VHL-binding warhead. This molecule is widely used as a critical building block to conjugate with ligands for proteins of interest (POIs) via a linker, thereby creating heterobifunctional degraders. By recruiting the VHL E3 ligase complex to the target protein, it facilitates the ubiquitination and subsequent proteasomal degradation of the POI. This approach has become a powerful strategy in chemical biology and drug discovery for targeting "undruggable" proteins. As a research-grade chemical probe, it is essential for developing novel therapeutics in oncology, neurodegenerative diseases, and other areas. Its role is strictly confined to the field of targeted protein degradation tool development and is not a general-purpose synthetic intermediate.