(S)-2-(1-Aminoethyl)-4-chlorophenol is a chiral aromatic amine derivative featuring a phenol group and a primary amine group on a stereogenic center. It serves as a key chiral building block in pharmaceutical synthesis. This compound is primarily utilized as a crucial intermediate in the synthesis of (S)-duloxetine, a widely prescribed serotonin-norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depressive disorder, generalized anxiety disorder, and certain types of chronic pain. The (S)-configuration of the aminoethyl side chain is essential for the desired biological activity of the final API. Its synthesis and application are of significant interest in process chemistry for the development of efficient and stereoselective routes to duloxetine and potentially other bioactive molecules containing similar structural motifs.