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    1228030-08-7

    Catalog No. EBD2305302

    CAS 1228030-08-7

    Name tert-butyl (3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylcarbamate compound with tert-butyl (3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-ylcarbamate (1:1)

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    Basic Information

    Synonyms: ((1S,5R,6S)-3-氮杂双环[3.3.0]辛烷-6-基)氨基甲酸叔丁酯 ((1S,5R,6S)-3-氮杂双环[3.3.0]辛烷-6-基)氨基甲酸叔丁酯 N - [(3aR,4S,6aS) - 八氢环戊[c]吡咯-4-基]氨基甲酸叔丁酯

    Molecular Formula: C12H22N2O2

    Molecular Weight: 226.32

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    This compound, known as tert-butyl ((1S,5R,6S)-3-azabicyclo[3.3.0]octan-6-yl)carbamate or its diastereomeric mixture, is a chiral bicyclic amine derivative. It features a fused cyclopentane-pyrrolidine (cyclopenta[c]pyrrolidine) core structure, which is a privileged scaffold in medicinal chemistry. The tert-butyloxycarbonyl (Boc) group serves as a standard protecting group for the amine functionality. Its primary and well-documented application is as a key chiral intermediate in the synthesis of pharmaceutical agents. Most notably, it is a critical building block in the industrial-scale production of Ticagrelor, a widely used antiplatelet drug (P2Y12 receptor antagonist) for the prevention of thrombotic events in patients with acute coronary syndrome. The specific stereochemistry of the bicyclic core is essential for the biological activity of the final drug molecule. The compound is typically handled as a high-purity solid and is commercially supplied for research and development as well as for cGMP manufacturing processes. Its synthesis and application underscore its importance as a specialized, high-value intermediate in modern asymmetric synthesis for the pharmaceutical industry.
    Physical Properties
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