Faropenem sodium, CAS No. 122547-49-3

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122547-49-3

Catalog No. EBD36993

CAS 122547-49-3

Name Faropenem sodium

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Basic Information

Synonyms: Faropenem Sodium faropenemsodium (5r-(3(r*),5-alpha,6-alpha(r*)))-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicacidmonosodiumsalt sodium(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Molecular Formula: C12H14NNaO5S

Molecular Weight: 307.3

MDL Number: MFCD01682061

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Faropenem sodium is a sodium salt of faropenem, a broad-spectrum oral penem antibiotic. It belongs to the β-lactam class of antibiotics, specifically the penems, which are structurally related to penicillins and carbapenems but possess a unique bicyclic core. This compound is the active pharmaceutical ingredient (API) in its prodrug form, faropenem medoxomil. Faropenem sodium exhibits antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, including many β-lactamase-producing strains. Its mechanism of action involves binding to penicillin-binding proteins (PBPs), thereby inhibiting bacterial cell wall synthesis. It is primarily used in the treatment of respiratory tract infections, urinary tract infections, and skin and soft tissue infections. As an API, it is formulated into oral dosage forms for clinical use. The development of faropenem aimed to combine the broad spectrum of carbapenems with the oral bioavailability of penicillins. Its stability against many β-lactamases contributes to its clinical utility. Handling requires standard precautions for potent APIs.

Physical Properties

Color: white to light brown

Boiling Point: 570.2 °C at 760 mmHg

Flash Point: 298.7 °C

Storage: −20°C

Analytical Data

Appearance: pale yellow crystals