Gemcitabine hydrochloride, CAS No. 122111-03-9

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122111-03-9

Catalog No. EBD6307

CAS 122111-03-9

Name Gemcitabine hydrochloride

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Basic Information

Synonyms: 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-onehydrochloride Gemcitabinehydrochloride 2',2'-Difluoro-2'-deoxycytidine 2,2-Difluoro-2-deoxycytidineDDFC GemcitabineHCl 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-one 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-onehydrochloride(1:1) Gemcitabinehydrochlorid 2',2'-Difluoro-2'-deoxycytidinehydrochloride 4-Amino-1-[3,3-dif

Molecular Formula: C9H12ClF2N3O4

Molecular Weight: 299.66

MDL Number: MFCD01735988

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Gemcitabine hydrochloride, with CAS number 122111-03-9, is the hydrochloride salt of gemcitabine, a synthetic nucleoside analog. Its chemical name is 2'-deoxy-2',2'-difluorocytidine monohydrochloride (β-isomer). It is a white to off-white crystalline powder that is soluble in water. This compound is a potent antineoplastic agent, primarily used as an active pharmaceutical ingredient (API) in the treatment of various cancers. Its main mechanism of action involves incorporation into DNA during replication, leading to inhibition of DNA synthesis and chain termination. It is a first-line therapy for pancreatic cancer, non-small cell lung cancer, bladder cancer, and breast cancer. As a key drug substance, it is also used as a reference standard in pharmaceutical quality control and research. Its impurities and degradation products are critical for analytical method development and validation, making it relevant as a pharmaceutical impurity standard.

Physical Properties

Melting Point: >250°C dec.

Boiling Point: 482.7 °C at 760 mmHg

Flash Point: 245.7 °C

Density: ==

Storage: room temp

Analytical Data

Appearance: White crystalline granular, odorless