N-Acetyl-L-tryptophan, CAS No. 1218-34-4

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1218-34-4

Catalog No. EBD32946

CAS 1218-34-4

Name N-Acetyl-L-tryptophan

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Basic Information

Synonyms: acetyl-l-tryptophane acetyl-l-tryptophan ac-trp-oh ac-tryptophan l-n-acetyl-2-amino-3-(3-indolyl)propionicacid l-acetyltryptophan h-n-acetyl-trp-oh rarechemahbs0070 N-Acetyl-L-tryptophan N-acetyltryptophan N-α-Acetyl-L-Tryptophan Ac-L-Trp-OH

Molecular Formula: C13H14N2O3

Molecular Weight: 246.26

MDL Number: MFCD00065976

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Medicinal Chemistry > Pharmaceutical Excipients > Novel and Functional Excipients

Product Description:

N-Acetyl-L-tryptophan (NAT) is a derivative of the essential amino acid L-tryptophan, characterized by an acetyl group attached to the amino nitrogen. It is a white to off-white crystalline powder with the molecular formula C13H14N2O3. Its primary application is in the pharmaceutical industry as a stabilizing excipient for protein-based therapeutics, particularly monoclonal antibodies and albumin solutions. It functions as an antioxidant and a stabilizer by scavenging reactive oxygen species and inhibiting oxidation of methionine and tryptophan residues in proteins, thereby preventing aggregation and degradation. This makes it a critical component in the formulation of biologics to ensure long-term stability and efficacy. Beyond its role as a pharmaceutical excipient, N-Acetyl-L-tryptophan is also used in biochemical research as a precursor or building block in peptide synthesis and metabolic studies. It has been investigated for its potential neuroprotective and anti-inflammatory properties in various research contexts.

Physical Properties

Melting Point: 186°C

Boiling Point: 586.6 °C at 760 mmHg

Flash Point: 308.6 °C

Storage: 2-8°C

Analytical Data

Appearance: solid