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    1213008-01-5

    Catalog No. EBD2900105

    CAS 1213008-01-5

    Name (R)-2-amino-2-(3,4-dichlorophenyl)ethanol

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    Basic Information

    Synonyms: (betaR)-beta-Amino-3,4-dichlorobenzeneethanol

    Molecular Formula: C8H9Cl2NO

    Molecular Weight: 206.07

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-2-amino-2-(3,4-dichlorophenyl)ethanol is a chiral amino alcohol derivative featuring a 3,4-dichlorophenyl substituent. It serves as a crucial chiral building block in pharmaceutical synthesis. The compound's structure, containing both a primary amine and a primary alcohol functional group, makes it a versatile intermediate for constructing more complex molecules with defined stereochemistry. Its primary application is as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Specifically, it is a vital precursor in the production of certain antidepressant and antipsychotic drugs, such as (R)-(-)-Reboxetine. The (R)-enantiomer is essential for imparting the desired biological activity, highlighting the importance of this chiral synthon in asymmetric synthesis and drug development. As a high-value pharmaceutical intermediate, it is typically handled under controlled conditions in research and manufacturing settings. Its synthesis and use are subjects of patents and specialized literature, focusing on efficient enantioselective routes to access this important scaffold for central nervous system (CNS) targeted therapies.
    Physical Properties
    mg g kg ml l t