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    1211565-08-0

    Catalog No. EBD4026316

    CAS 1211565-08-0

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    Basic Information

    Molecular Formula: C22H26F3N3O2

    Molecular Weight: 421.46

    Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Targeted Protein Degradation Tools > Ligand-Linker Conjugates

    Product Description:
    This compound, with CAS number 1211565-08-0, is a chemical entity featuring a cyclobutenedione core substituted with a ((1R,2R)-2-(piperidin-1-yl)cyclohexyl)amino group and a (4-(trifluoromethyl)phenyl)amino group. It is a key intermediate in the synthesis of more complex molecular structures. Its primary and well-documented application is in the field of targeted protein degradation. Specifically, it serves as a crucial component or a direct precursor in the development of Proteolysis-Targeting Chimeras (PROTACs). These are bifunctional molecules designed to recruit E3 ubiquitin ligases to target specific proteins of interest for ubiquitination and subsequent degradation by the proteasome. The structural motifs present in this compound are characteristic of ligands or linkers used in such degraders. Research indicates its significance in the synthesis of potent and selective degraders targeting various disease-relevant proteins, particularly in oncology. Its role underscores its importance as a specialized tool compound in modern drug discovery, bridging medicinal chemistry and chemical biology to explore new therapeutic modalities.
    Physical Properties
    mg g kg ml l t