This compound, with CAS number 1211565-07-9, is a chemical entity featuring a 3-cyclobutene-1,2-dione core substituted with a 3,5-bis(trifluoromethyl)phenylamino group and a ((1R,2R)-2-(dimethylamino)cyclohexyl)amino group. Its structure is characterized by the presence of trifluoromethyl groups and a chiral cyclohexylamine moiety. Extensive research identifies this molecule as a key component in the development of Proteolysis-Targeting Chimeras (PROTACs). Specifically, it serves as a ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase. The compound's structure is designed to bind with high affinity to the VHL protein, making it a crucial building block for constructing VHL-based PROTAC degraders. These degraders are bifunctional molecules that recruit target proteins to the VHL complex for ubiquitination and subsequent proteasomal degradation. As a VHL ligand-linker conjugate precursor, this compound is a vital tool in chemical biology and drug discovery for targeted protein degradation. It enables the exploration of novel therapeutic strategies for diseases previously considered "undruggable" by conventional small-molecule inhibitors.