(2R,4S)-1-Benzylazetidine-2,4-dicarboxylic acid dimethyl ester is a chiral azetidine derivative featuring two ester groups and a benzyl substituent on the nitrogen atom. The trans configuration of the substituents on the four-membered azetidine ring is a key structural feature. It is a high-purity building block commonly supplied as a single enantiomer. This compound is primarily utilized as a chiral intermediate in pharmaceutical research and development. The azetidine scaffold is a valuable motif in medicinal chemistry due to its conformational rigidity and potential for modulating the physicochemical and biological properties of drug candidates. This specific derivative serves as a precursor for synthesizing more complex molecules containing the azetidine ring, which may be explored for various therapeutic targets. As a versatile chiral synthon, it is employed in the construction of novel chemical entities. Its availability as a defined stereoisomer makes it particularly useful for studying structure-activity relationships (SAR) and for the efficient synthesis of enantiomerically pure potential active pharmaceutical ingredients (APIs) or advanced intermediates.