4-Chloro-3-sulfamoylbenzoic acid, CAS No. 1205-30-7

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1205-30-7

Catalog No. EBD35264

CAS 1205-30-7

Name 4-Chloro-3-sulfamoylbenzoic acid

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Basic Information

Synonyms: 4-Chloro-3-sulfamoylbenzoicacid 3-(aminosulfonyl)-4-chloro-benzoicaci 4-chloro-3-sulfamoyl-benzoicaci csba 4-chloro-3-sulfaminebenzoicacid 4-chloro-3-sulfonamidobenzoicacid 4-chloro-3-sulphamoylbenzoicacid 4-chloro-5-sulphamoylbenzoicacid 4-Chloro-3-SulfomulbenzoicAcid 3-(Aminosulfonyl)-4-chlorobenzoicAcid 3-Aminosulfonyl-4-chlorobenzoicacid 4-chloro-3-sulfamoylbenzoate 4-chloro-3-sulfamoyl

Molecular Formula: C7H6ClNO4S

Molecular Weight: 235.64

MDL Number: MFCD00012375

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

Product Description:

4-Chloro-3-sulfamoylbenzoic acid is a white to off-white crystalline powder. It is a key synthetic intermediate in the pharmaceutical industry, most notably for the production of loop diuretics. Its molecular structure features a benzoic acid core substituted with a chloro group and a sulfamoyl group at the 4- and 3- positions, respectively. The primary and most significant application of this compound is as a crucial building block in the synthesis of bumetanide, a potent loop diuretic medication. Bumetanide is used to treat edema associated with congestive heart failure, liver disease, and kidney disease. The sulfamoyl and carboxylic acid functionalities in 4-chloro-3-sulfamoylbenzoic acid are essential pharmacophores that are retained and further modified to create the final active pharmaceutical ingredient (API). As a pharmaceutical intermediate, it is handled under controlled conditions in accordance with Good Manufacturing Practice (GMP) standards. Its synthesis and purification are critical steps to ensure the quality and efficacy of the final drug product.

Physical Properties

Melting Point: 256-258 °C(lit.)

Boiling Point: 502.4 °C at 760 mmHg

Flash Point: 257.6 °C

Density: 1.649 g/cm3

Analytical Data

Appearance: White powder