2,5 - Difluorobenzenesulphonamide, CAS No. 120022-63-1

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120022-63-1

Catalog No. EBD14443

CAS 120022-63-1

Name 2,5 - Difluorobenzenesulphonamide

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Basic Information

Synonyms: 2,5-DIFLUOROBENZENESULFONAMIDE BUTTPARK21\07-14 2,5-DIFLUOROBENZENESULPHONAMIDE Benzenesulfonamide,2,5-difluoro-(9CI) 2,5-Difluoro-benzenesulfonamide benzenesulfonamide,2,5-difluoro-

Molecular Formula: C6H5F2NO2S

Molecular Weight: 193.17

MDL Number: MFCD00798115

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

2,5-Difluorobenzenesulfonamide is an organic compound featuring a benzene ring substituted with two fluorine atoms at the 2- and 5- positions and a sulfonamide group. It serves as a versatile and valuable building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of pharmaceutical compounds. The presence of both fluorine atoms and the sulfonamide moiety makes it a crucial precursor for developing molecules with potential biological activity. It is notably used in the research and development of kinase inhibitors and other small molecule drugs, where the sulfonamide group can act as a bioisostere or participate in hydrogen bonding interactions with target proteins. As a bifunctional synthon, it is employed in various coupling reactions and further functionalizations. The fluorine atoms provide sites for selective substitution, while the sulfonamide group can be modified or used to introduce additional complexity into target molecules.

Physical Properties

Melting Point: 135-139 °C(lit.)

Boiling Point: 320.144 °C at 760 mmHg

Flash Point: 147.418 °C

Density: 1.523 g/cm3