2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-onehydrochloride, CAS No. 120011-70-3

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120011-70-3

Catalog No. EBD893816

CAS 120011-70-3

Name 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-onehydrochloride

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Basic Information

Synonyms: Donepezilhydrochloride DonepezilHCl Aricept,E-2020DonepezilHCl 2-(1-Benzylpiperidin-4-ylmethyl)-5,6-dimethoxyindan-1-onehydrochloride 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-onehydrochloride AKOS226-31 E-2020 ARICEPT DonepezilHcl120011-70-3 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-onehydrochloride(1:1) 2,3-dihydro-5,6-dimethoxy-2-{[1-(phemylmethyl)-4-piperidinyl]methyl}-1H-indan-1-oneHCL Donezepilhydrochloride

Molecular Formula: C24H30ClNO3

Molecular Weight: 415.95

MDL Number: MFCD00881312

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

This compound, with the CAS number 120011-70-3, is chemically identified as 2,3-dihydro-5,6-dimethoxy-2-{[(1-benzyl)-4-piperidinyl]methyl}-1H-inden-1-one hydrochloride. It is a synthetic organic molecule featuring a complex structure that combines an indanone core with a benzylpiperidine moiety, connected via a methylene linker. The presence of the hydrochloride salt indicates its formulation as a pharmaceutically relevant salt form, typically to enhance solubility and stability. Extensive research and patent literature identify this compound as a key intermediate in the synthesis of Donepezil Hydrochloride. Donepezil is a well-known acetylcholinesterase inhibitor and is a globally marketed active pharmaceutical ingredient (API) for the treatment of Alzheimer's disease and other forms of dementia. As such, this specific intermediate is of paramount importance in the pharmaceutical manufacturing process of this central nervous system drug. The synthesis and purification of this high-purity intermediate are critical steps in ensuring the quality and efficacy of the final drug product. Its handling requires standard laboratory safety precautions for fine chemicals, including the use of personal protective equipment due to its potential irritant properties.

Physical Properties

Melting Point: 220-222°C

Boiling Point: 527.9 °C at 760 mmHg

Flash Point: 273.1 °C

Analytical Data

Appearance: white to off-white crystalline solid