Ethyl N-piperazinecarboxylate, CAS No. 120-43-4

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120-43-4

Catalog No. EBD29258

CAS 120-43-4

Name Ethyl N-piperazinecarboxylate

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Basic Information

Synonyms: ethyl1-piperazinocarboxylate ethyl-piperazinocarboxylate n-(ethoxycarbonyl)piperazine piperazineethylcarboxylate piperazine-n-carboxylicacidethylester 1-PiperazinecarboxylicAcidEthylEster Ethylpiperazine-1-carboxylate Ethylcarbonyl piperazine Piperazine ethylcarboxylate Piperazine-N-carboxylic EthylN-piperazinecarboxylate 1-Carbethoxypiperazine

Molecular Formula: C7H14N2O2

Molecular Weight: 158.2

MDL Number: MFCD00005964

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Ethyl N-piperazinecarboxylate is a versatile heterocyclic building block featuring a piperazine ring substituted with an ethyl carbamate group. It is a colorless to pale yellow liquid with a molecular formula of C7H14N2O2 and is commonly used as a key intermediate in organic synthesis. Its primary and most significant application is in the pharmaceutical industry, where it serves as a crucial precursor for the synthesis of various active pharmaceutical ingredients (APIs). Notably, it is a key intermediate in the production of important drugs such as the antipsychotic agent aripiprazole and the antidepressant trazodone. The piperazine moiety is a privileged scaffold in medicinal chemistry, and this compound provides a protected and reactive handle for further functionalization. Beyond its pharmaceutical applications, it is also employed as a general-purpose amine reagent and building block in research and development for constructing more complex molecules, particularly those containing the piperazine pharmacophore. It is commercially available and should be handled with standard precautions for organic amines.

Physical Properties

Melting Point: 120 °C

Boiling Point: 273 °C(lit.)

Flash Point: 113 °C

Density: 1.08 g/mL at 25 °C(lit.)

Solubility: soluble

Refractivity: n20/D 1.477(lit.)

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2810

Analytical Data

Appearance: clear light yellow oily liquid