Tropine, CAS No. 120-29-6

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120-29-6

Catalog No. EBD2197957

CAS 120-29-6

Name Tropine

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Basic Information

Synonyms: Tropine timtec-bbsbb006506 n-methyl-8-azabicyclo[3.2.1]octan-3-ol tropan-3alpha-ol tropanol endo-8-methyl-8-azabicyclo[3,2.1]octan-3-ol 8-aza-n-methylbicyclo-[3.2.1]octan-3-ol 3-tropanol endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (1R,5S)-3-hydroxy-8-methyl-8-azoniabicyclo[3.2.1]octane (3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol α-Tropine

Molecular Formula: C8H15NO

Molecular Weight: 141.21

MDL Number: MFCD00005551

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Α-Tropine, also known as tropine, is a bicyclic amino alcohol with the chemical formula C8H15NO. It is a key structural component of the tropane alkaloid family, featuring a fused azabicyclo[3.2.1]octane ring system. This compound is a white crystalline solid at room temperature. Its primary and most significant application is as a crucial intermediate in the pharmaceutical synthesis of important anticholinergic drugs. Most notably, it is a direct precursor in the manufacturing of atropine and scopolamine (hyoscine). These drugs are active pharmaceutical ingredients (APIs) used in various therapeutic areas, including as pre-anesthetic agents to reduce secretions, as antidotes for certain poisonings, and in the treatment of motion sickness and gastrointestinal spasms. Due to its specific and high-value role in producing these established nervous system drugs, α-tropine is predominantly classified as a pharmaceutical intermediate. Its use is largely confined to specialized organic synthesis within the fine chemical and pharmaceutical industries, rather than as a general-purpose building block or reagent.

Physical Properties

Melting Point: 50-60 °C(lit.)

Boiling Point: 233 °C(lit.)

Flash Point: 232-234°C

Density: 1.045 g/mL at 25 °C(lit.)

Solubility: H2O: 0.1 g/mL, clear

Storage: 2-8°C

Analytical Data

Appearance: white to slightly yellow crystalline powder