(S)-2-Amino-3-(thiazol-4-yl)propanoic acid, CAS No. 119433-80-6

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119433-80-6

Catalog No. EBD18141

CAS 119433-80-6

Name (S)-2-Amino-3-(thiazol-4-yl)propanoic acid

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Basic Information

Synonyms: 3-(4-Thiazolyl)-L-alanine L-4-THIAZOLYLALANINE RARECHEMBKPTF199 (S)-3-(4-THIAZOLYL)-ALANINE H-ALA(4-THIAZOYL)-OH H-ALA(4-THZ)-OH 3-(4-THIAZOYL)-L-ALANINE N-(tert-butoxycarbonyl)-3-(1,3-thiazol-4-yl)-L-alanine 3-(1,3-thiazol-4-yl)-L-alanine (2R)-2-ammonio-3-(1,3-thiazol-4-yl)propanoate L-4-Thiazoylalanine

Molecular Formula: C6H8N2O2S

Molecular Weight: 172.2

MDL Number: MFCD00079677

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

3-(4-Thiazolyl)-L-alanine is a non-proteinogenic amino acid derivative characterized by a thiazole ring attached to the side chain of L-alanine. This structure makes it a valuable chiral building block in organic synthesis and medicinal chemistry. Its primary application is in the research and development of pharmaceuticals. It serves as a key intermediate in the synthesis of various biologically active compounds, particularly those targeting the central nervous system. For instance, it is a crucial precursor in the synthesis of potent and selective agonists for metabotropic glutamate receptors (mGluRs), which are important targets for treating neurological disorders such as anxiety, depression, and schizophrenia. As a functionalized amino acid containing a heterocyclic moiety, it is also utilized in peptide modification and the construction of more complex molecular architectures for drug discovery. Its chirality and specific functional groups make it a specialized reagent rather than a general-purpose synthetic block.

Physical Properties

Boiling Point: 353.3 °C at 760 mmHg

Flash Point: 167.5 °C

Density: 1.433 g/cm3

Storage: Store at -15°C