3-Quinuclidinone hydrochloride, CAS No. 1193-65-3

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1193-65-3

Catalog No. EBD31454

CAS 1193-65-3

Name 3-Quinuclidinone hydrochloride

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Basic Information

Synonyms: 3-aminoquinuclidinonehydrochloride 3-quinuclidinonehcl 3-quinuclidonehydrochloride 1-aza-3-oxobicyclo[2.2.2]octanehydrochloride 3-quinuclidionehcl 1-AZABICYCLO(2.2.2)OCTAN-3-ONE 1-Azabicyclo[2.2.2]octan-3-on 1-Azabicyclo[2,2,2]octan-3-onehydrochloride 1-azabicyclo[2.2.2]octan-3-onehydrochloride(1:1) 1-Azabicyclo[2.2.2]octan-3-oneHydrochloride Quinuclidin-3-onehydrochloride 3-Quinuclidinonehydrochloride

Molecular Formula: C7H12ClNO

Molecular Weight: 161.63

MDL Number: MFCD00137391

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-Quinuclidinone hydrochloride is an organic salt consisting of the bicyclic tertiary amine 3-quinuclidinone and hydrochloric acid. It is a white to off-white crystalline powder with a molecular formula of C7H12ClNO. The compound features a rigid, bridged azabicyclic structure, which is a key pharmacophore in medicinal chemistry. This compound is a crucial intermediate in the synthesis of numerous pharmaceutical agents. Its primary application is in the production of anticholinergic and antimuscarinic drugs. Most notably, it serves as a key building block for the synthesis of solifenacin succinate, a medication used to treat overactive bladder syndrome. The quinuclidine scaffold is valued for its ability to impart specific three-dimensional geometry and receptor-binding properties to drug molecules. Beyond its direct pharmaceutical use, 3-quinuclidinone hydrochloride is also employed as a versatile synthetic building block in organic chemistry. Its structure makes it a valuable precursor for the development of other nitrogen-containing heterocycles and for studying structure-activity relationships in drug discovery programs.

Physical Properties

Melting Point: >300 °C (dec.)(lit.)

Boiling Point: 204.9ºCat 760 mmHg

Flash Point: 78.1ºC

Solubility: H2O: 0.1 g/mL, clear

Storage: 2-8°C

Analytical Data

Appearance: white or yelloish powder