(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, CAS No. 118864-75-8

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118864-75-8

Catalog No. EBD2201993

CAS 118864-75-8

Name (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

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Basic Information

Synonyms: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline (S)-1,2,3,4-TETRAHYDRO-1-PHENYLISOQUINOLINE (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Solifenacin(YM905)intermediate10 (1S)-1,2,3,4-Tetrahydro-1-(phenyl-d5)isoquinoline (S)-1-(Phenyl-d5)-1,2,3,4-tetrahydroisoquinoline (S)-1-1-Phenyl-1,2,3,4-Tetrahy (S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Molecular Formula: C15H15N

Molecular Weight: 209.29

MDL Number: MFCD08692036

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral amine compound featuring a tetrahydroisoquinoline scaffold substituted with a phenyl group at the 1-position. This structure is a versatile and important chiral building block in organic synthesis, particularly valued for its rigid, fused bicyclic system and its stereogenic center. Its primary and most significant application is in pharmaceutical research and development as a key chiral intermediate. The tetrahydroisoquinoline core is a privileged structure found in numerous bioactive molecules. This specific (S)-enantiomer is employed in the synthesis of various pharmacologically active compounds, including potential candidates for central nervous system (CNS) agents and other therapeutic areas. Its chirality is crucial for imparting specific biological activity and selectivity in the final drug molecules. Beyond its role as a pharmaceutical intermediate, it serves as a valuable chiral ligand precursor or organocatalyst in asymmetric synthesis due to its basic nitrogen atom and stereochemistry. It is commercially available from suppliers specializing in fine chemicals and chiral building blocks for medicinal chemistry.

Physical Properties

Melting Point: 80-82°C

Boiling Point: 338°C

Flash Point: 167°C

Density: 1.065

Analytical Data

Appearance: white solid