N-Acetyl-L-leucine, CAS No. 1188-21-2

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1188-21-2

Catalog No. EBD14032

CAS 1188-21-2

Name N-Acetyl-L-leucine

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Basic Information

Synonyms: Ac-Leu-OH N-acetylleucine (2S)-2-(acetylamino)-4-methylpentanoate leucine,n-acetyl-,l- l-leucine,n-acetyl- n-acetyl-l-lenucine n-acetyl-l-leucin (s)-n-acetylleucine (s)-2-acetylamino-4-methyl-pentanoicacid n-alpha-acetyl-l-leucine n-alpha-acetyl-dl-leucine Trifluoro(trifluoromethoxy)ethylene N-Acetyl-L-leucine ac-leucine ac-dl-leu-oh n-acetyl-dl-leu acetyl-l-leucine acetyl-dl-leucine n-acetyl-dl-leucine acetyl-dl-leucine,n-

Molecular Formula: C8H15NO3

Molecular Weight: 173.21

MDL Number: MFCD00065131

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Medicinal Chemistry > Pharmaceutical Excipients > Novel and Functional Excipients

Product Description:

N-Acetyl-L-leucine is a derivative of the essential branched-chain amino acid L-leucine, where the amino group is acetylated. It is a white crystalline powder with the molecular formula C8H15NO3 and a molecular weight of 173.21 g/mol. This modification enhances its lipophilicity and metabolic stability compared to the parent amino acid. Its primary and most significant application is in the pharmaceutical field. N-Acetyl-L-leucine is the active pharmaceutical ingredient (API) in the prescription medication Tanganil, used for the symptomatic treatment of vertigo and dizziness, particularly in conditions like acute vestibular syndrome. It is believed to act by modulating cerebellar activity and facilitating vestibular compensation. Beyond its use as an API, it also finds application as a functional excipient or a chiral building block in peptide synthesis and pharmaceutical formulations. Research continues to explore its potential neuroprotective effects and other therapeutic benefits. As a derivative of a natural amino acid, it is generally considered to have a favorable safety profile.

Physical Properties

Melting Point: 187-190 °C(lit.)

Boiling Point: 369.7 °C at 760mmHg

Flash Point: 177.4 °C

Density: 1.069 g/cm3

Solubility: 0.81 g/100 mL (20 ºC)

Refractivity: -22 ° (C=5, EtOH)

Storage: −20°C

Analytical Data

Appearance: white crystalline powder