Ceftibuten dihydrate, CAS No. 118081-34-8

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118081-34-8

Catalog No. EBD8579

CAS 118081-34-8

Name Ceftibuten dihydrate

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Basic Information

Synonyms: (+)-(6R,7R)-7-[2-(2-Amino-1,3-thiazol-4-yl)-4-carboxy-2-butenamide]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicaciddihydrate Ceftibutendihydrate Sch-39720 (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicaciddihydrate (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic

Molecular Formula: C15H18N4O8S2

Molecular Weight: 446.46

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Cefibuten dihydrate is a third-generation oral cephalosporin antibiotic. It is a white to pale yellowish-white crystalline powder. Structurally, it is a β-lactam antibiotic belonging to the cephalosporin class, characterized by a cephem nucleus. Its primary and definitive application is as an active pharmaceutical ingredient (API) for the treatment of bacterial infections. Cefibuten exhibits broad-spectrum antibacterial activity, particularly effective against Gram-negative bacteria such as *Haemophilus influenzae*, *Moraxella catarrhalis*, and *Escherichia coli*. It is commonly formulated into capsules or dry syrup for oral administration, used to treat conditions like bronchitis, tonsillitis, and otitis media. The compound works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. It is generally well-tolerated, with common side effects being gastrointestinal disturbances. As a finished drug substance, it is not typically used as a synthetic building block in other chemical syntheses, solidifying its classification strictly within the pharmaceutical domain.

Physical Properties

Melting Point: 180 °C (dec.)"> >180 °C (dec.)

Boiling Point: 966.4 °C at 760 mmHg

Flash Point: 538.3 °C

Analytical Data

Appearance: Light-yellow solid