(3R,4R)-3-Fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester is a chiral piperidine derivative characterized by a fluorine atom and a hydroxyl group at the 3- and 4-positions, respectively, both in the *R* configuration. The nitrogen atom is protected by a tert-butoxycarbonyl (Boc) group, making it a stable and versatile building block for synthetic chemistry. This compound serves as a crucial chiral intermediate in the pharmaceutical industry. Its primary application is in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS). The fluorinated, hydroxylated piperidine scaffold is a privileged structure found in several bioactive compounds and active pharmaceutical ingredients (APIs). The Boc-protected amine allows for selective deprotection and further functionalization, facilitating its incorporation into target molecular frameworks. As a high-value synthetic intermediate, it is typically used in research and development settings for constructing novel chemical entities. Its chirality is essential for achieving the desired biological activity and selectivity in the final drug candidate.