Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    116169-90-5

    Catalog No. EBD37215

    CAS 116169-90-5

    Name (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-6-(2,2,2-trifluoroacetamido)hexanoic acid

    Get Quote
    Basic Information

    Synonyms: N2-(1S-Ethoxycarbonyl-3-Phenylpropyl)-N6-Trifluoroacetyl-L-Lysine (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-6-(2,2,2-trifluoroacetamido)hexanoicacid

    Molecular Formula: C20H27F3N2O5

    Molecular Weight: 432.43

    MDL Number: MFCD06658211

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

    Product Description:
    N2-(1-Ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine is a protected lysine derivative, specifically designed as a key synthetic intermediate. Its structure features an N-terminal protecting group (1-ethoxycarbonyl-3-phenylpropyl) and a side-chain protecting group (trifluoroacetyl, TFA) on the ε-amino group of the L-lysine backbone. This dual protection strategy is crucial for controlling regioselectivity during peptide bond formation. This compound is primarily employed in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics. The TFA group on the side chain is a common, acid-labile protecting group that can be selectively removed under mild conditions (e.g., using piperidine), allowing for the sequential elongation of peptide chains. Its main application lies in the research and development of bioactive peptides, including potential pharmaceutical candidates. As a specialized, non-commercial building block, it is not a generic chemical reagent. Its value is defined by its role in constructing specific peptide sequences for medicinal chemistry and biochemical research, rather than in broad organic synthesis.
    Physical Properties

    Melting Point: 134-136°C

    Boiling Point: 586.987 °C at 760 mmHg

    Flash Point: 308.799 °C

    Density: 1.234 g/cm3

    Analytical Data

    Appearance: White solid

    mg g kg ml l t