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    114748-67-3

    Catalog No. EBD3333468

    CAS 114748-67-3

    Name 2-amino-3,7-dihydro-5-iodo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-4H-Pyrrolo[2,3-d]pyrimidin-4-one

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    Basic Information

    Synonyms: 2-amino-3,7-dihydro-5-iodo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-4H-Pyrrolo[2,3-d]pyrimidin-4-one

    Molecular Formula: C11H13IN4O3

    Molecular Weight: 376.15

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

    Product Description:
    This compound, with the CAS number 114748-67-3, is a complex heterocyclic molecule. Its systematic name is 2-Amino-3,7-dihydro-5-iodo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-4H-pyrrolo[2,3-d]pyrimidin-4-one. The structure features a pyrrolo[2,3-d]pyrimidine core, which is a bicyclic heterocyclic system, substituted with an amino group, an iodine atom, and a tetrahydrofuran ring bearing a hydroxymethyl group. This molecule is a key synthetic intermediate in the production of nucleoside analogues. Specifically, it is a crucial precursor in the synthesis of the antiviral drug **Entecavir**, which is a potent and selective inhibitor of hepatitis B virus (HBV) replication. The iodine atom and the specific stereochemistry of the tetrahydrofuran moiety are essential for the subsequent steps that construct the final carbocyclic nucleoside structure of Entecavir. As a specialized building block for a specific active pharmaceutical ingredient (API), its primary and almost exclusive application is within pharmaceutical research and manufacturing processes. Its synthesis and handling require expertise in nucleoside chemistry and asymmetric synthesis due to its chiral centers and functional group complexity.
    Physical Properties
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