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    1143532-39-1

    Catalog No. EBD2206924

    CAS 1143532-39-1

    Name AZD5363

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    Basic Information

    Synonyms: 4-Piperidinecarboxamide,4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- AZD5363 AZD-5363 Capivasertib (AZD5363)

    Molecular Formula: C21H25ClN6O2

    Molecular Weight: 428.92

    Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide is a complex heterocyclic compound featuring a pyrrolo[2,3-d]pyrimidine core linked to a piperidinecarboxamide moiety. It is a key intermediate in the synthesis of the Bruton's tyrosine kinase (BTK) inhibitor, Ibrutinib (PCI-32765). This compound serves as a crucial advanced building block for constructing the final active pharmaceutical ingredient (API). Its structure contains the essential pharmacophore elements required for BTK binding and inhibition. The synthesis and purification of this intermediate are critical steps in the manufacturing process of Ibrutinib, a targeted therapy used for treating B-cell malignancies such as mantle cell lymphoma and chronic lymphocytic leukemia. As a high-value synthetic intermediate, its production and quality control are subject to stringent pharmaceutical standards. It is not typically used as a general-purpose synthetic reagent but is specifically designed and optimized for the efficient and scalable synthesis of the final drug substance.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t