2-(3-Hydroxy-4-methoxyphenyl)acetic acid, CAS No. 1131-94-8

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1131-94-8

Catalog No. EBD10085

CAS 1131-94-8

Name 2-(3-Hydroxy-4-methoxyphenyl)acetic acid

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Basic Information

Synonyms: homoisovanillicacid 3-hydroxy-4-methoxyphenylaceticacid 2-(3-hydroxy-4-methoxy-phenyl)aceticacid isohomovanillicacid 3-hydroxy-4-methoxyphenylaceticacid,98% 3-hydroxy-4-methoxybenzeneaceticacid 4-methoxy-3-hydroxyphenylaceticacid methyl2-(3-hydroxy-4-methoxyphenyl)acetate Homo-iso-vanillicacid 2-(3-hydroxy-4-methoxyphenyl)aceticacid

Molecular Formula: C9H10O4

Molecular Weight: 182.17

MDL Number: MFCD00016829

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

3-Hydroxy-4-methoxyphenylacetic acid is an organic compound featuring a phenylacetic acid core substituted with a hydroxy group at the 3-position and a methoxy group at the 4-position. It is a white to off-white crystalline powder. This compound is primarily recognized as a key intermediate in the synthesis of important pharmaceutical agents. Its most notable application is in the production of the anti-Parkinson's drug, Levodopa (L-DOPA). It serves as a crucial building block in multi-step synthetic routes to construct the catecholamine backbone of L-DOPA. Additionally, it is used in the synthesis of other pharmaceutical compounds, including certain beta-adrenergic receptor agonists. As a versatile synthon, it participates in various organic transformations typical of aromatic acids and phenols, such as esterification and etherification. Proper handling precautions are advised as it may cause skin and eye irritation.

Physical Properties

Melting Point: 127-132 °C

Boiling Point: 371.3 °C at 760 mmHg

Flash Point: 153.1 °C

Density: 1.307 g/cm3