Fmoc-D-methionine, CAS No. 112883-40-6

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112883-40-6

Catalog No. EBD38863

CAS 112883-40-6

Name Fmoc-D-methionine

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Basic Information

Synonyms: fmoc-D-methionine Fmoc-D-Met-OH NALPHA-9-Fluorenylmethoxycarbonyl-D-methionine N-[(9H-fluoren-9-ylmethoxy)carbonyl]methionine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-methionine N-FMOC-D-METHIONINE N-ALPHA-FMOC-D-METHIONINE N-(9-FLUORENYLMETHOXYCARBONYL)-D-METHIONINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-METHIONINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-METHIONINE 9-FLUORENYLMETHOXYCARBONYL-D-METHIONINE FMOC-D-MET N-(9-Fluorenylmethyloxycarbonyl)-D-methionine Fmoc-Met-OH

Molecular Formula: C20H21NO4S

Molecular Weight: 371.45

MDL Number: MFCD00062958

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-D-Methionine, with CAS number 112883-40-6, is a protected amino acid derivative. It features a fluorenylmethyloxycarbonyl (Fmoc) group protecting the amine functionality and the D-enantiomer of the sulfur-containing amino acid methionine. This compound is a fundamental building block in solid-phase peptide synthesis (SPPS) employing the Fmoc strategy. The Fmoc group serves as an orthogonal protecting group that can be removed under mild basic conditions (e.g., piperidine), allowing for the sequential assembly of peptide chains. The D-methionine residue is specifically incorporated to modulate the biological activity, stability, and pharmacokinetic properties of synthetic peptides, which are crucial in pharmaceutical research and drug development. As a high-purity chiral synthon, it is essential for producing peptides with defined stereochemistry for use as therapeutic agents, diagnostic tools, and biochemical probes. Proper handling is required due to its sensitivity to light and oxidizing agents.

Physical Properties

Melting Point: 120-124 °C

Boiling Point: 614.6 °C at 760 mmHg

Flash Point: 325.5 °C

Density: 1.282 g/cm3

Refractivity: 30 ° (C=1, DMF)

Storage: 2-8°C